Pete Gueldner is a Postdoctoral Associate in Jay Humphrey’s Continuum Biomechanics Laboratory at Yale University. His research investigates how cellular signaling and extracellular matrix remodeling govern vascular adaptation, mechanical vulnerability, and failure.

He combines spatial matrix characterization, multiphoton imaging, biaxial and inflation-based mechanical testing, and computational mechanobiology to connect cell-regulated changes in matrix density and organization with tissue-level function. His experimental work includes the development of methods to assess the strength of vascular tissue.

His long-term research vision couples multicellular signaling networks with constrained-mixture models of vascular growth and remodeling. Mechanistically informed artificial intelligence, including graph-based neural networks, will help explore how specific perturbations change matrix state and failure vulnerability over time.

Originally from San Antonio, Texas, Pete earned his B.S. in Biomedical Engineering with a minor in Mathematics at the University of Texas at San Antonio, and his Ph.D. in Bioengineering at the University of Pittsburgh in 2025.